First discovered more than 20 years ago, PINK1 is a protein directly linked to Parkinson’s disease, but until now, no one has seen what human PINK1 looks like, or how PINK1 attaches to ...

Experts have known for several decades that the PINK1 protein is directly linked to Parkinson’s disease – the fastest growing ...

View Full Profile. Learn about our Editorial Policies. PINK1 triggers a downstream cascade of events that leads to mitophagy—a process by which the cell clears away any mitochondria it doesn’t need. 4 ...

But in a recent paper published in Science, researchers have had their first good gawk at the protein linked to the development of the condition (PTEN-induced putative kinase 1, or PINK1).

A report published in PLoS Biology provides evidence that PTEN-induced putative kinase 1 (PINK1) is involved in selective autophagy of dysfunctional mitochondria. Recessive mutations in the PINK1 ...

Two of the proteins, Parkin and PINK1, hang around the mitochondria’s membrane and work as a pair to enable the mitochondria to fuse or degrade. Abnormalities in the genes for Parkin and PINK1 are ...

“GO and KEGG pathway analysis from RNA sequencing showed that PINK1/Parkin-mediated mitophagy pathway was enriched in 786-O-PR. Silencing SLC27A3 significantly reduced the accumulation of LD and ...

Our most recent work is focused on elucidating how a protein kinase (PINK1) controls the activity of a ubiquitin E3 ligase (Parkin) to specify cell fate decisions. Mutations in genes encoding for ...