Mandimycin, which targets a different essential fungi cell resource than other antifungal drugs, should harm other cell types as collateral — but doesn’t.

Antifungal drugs target molecules in the fungal cell wall, a flexible but rigid outer layer that provides the cell protection. By rupturing the protective structure, the drugs kill the fungal cell ...

This fascinating compound is a probable treasure trove of actionable intelligence in the battle against drug-resistant fungal infections ... as part of its chemical structure.

Only four new antifungal drugs were approved over the last decade. The WHO urges for safer treatments and improved diagnostics, especially in low and middle-income countries, to address this ...