The Death Of Her Sister Alexis Arquette Was Devastating In September of 2016, Patricia Arquette suffered a heartbreaking loss when her sister Alexis Arquette passed away from complications of HIV.

Patricia Arquette is one of many members of her family ... impact on the industry beyond acting before her untimely death ...

Patricia Arquette, who starred in Lynch’s 1997 neo-noir thriller Lost Highway, mourned the filmmaker as she learned of the his death during an interview on Thursday, hours after he died at age 78.