Thus, while Ace’s death stands as one of the saddest moments in One Piece ... The manga eventually gave way to the anime series, with the two being some of history's longest-running anime ...

These are anime's saddest series of all time, with heartbreaking stories of tragedy that will have an impact on fans for years to come.

With the Infinity Castle arc about to be animated, fans may wish to revisit the many sacrifices the Demon Slayer Corps have made. Here are our top 5 saddest deaths from the series.