New observations of the early stages of tuberculosis infection may turn scientists' understanding of the bug's pathogenesis on its head: clumps of immune cells, called granulomas, long thought to ...

Different types of immune cells form, so-called granulomas, in which M. tuberculosis can survive for years (latent infection). They fall into a permanently inactive state with reduced metabolic ...

Advanced multiplexed imaging shows in how the immune response to Mtb when unvaccinated is very inflammatory and results in structures called granulomas, which are dense collections of immune cells ...

More information: Chanchal Sur Chowdhury et al, Type I IFN-mediated NET release promotes Mycobacterium tuberculosis replication and is associated with granuloma caseation, Cell Host & Microbe (2024).

EVERYTHING IS TUBERCULOSIS: The History and Persistence of Our Deadliest Infection, by John Green Tuberculosis kills more people — over a million a year worldwide — than any other infectious ...