Experts have known for several decades that the PINK1 protein is directly linked to Parkinson’s disease – the fastest growing ...

First discovered more than 20 years ago, PINK1 is a protein directly linked to Parkinson’s disease, but until now, no one has seen what human PINK1 looks like, or how PINK1 attaches to ...

The PINK1 protein is an important maintenance worker in the body. In healthy mitochondria, the protein passes through the outer and inner membranes, where it sinks out of sight. In mitochondria ...

A report published in PLoS Biology provides evidence that PTEN-induced putative kinase 1 (PINK1) is involved in selective autophagy of dysfunctional mitochondria. Recessive mutations in the PINK1 ...

Two of the proteins, Parkin and PINK1, hang around the mitochondria’s membrane and work as a pair to enable the mitochondria to fuse or degrade. Abnormalities in the genes for Parkin and PINK1 are ...

But in a recent paper published in Science, researchers have had their first good gawk at the protein linked to the development of the condition (PTEN-induced putative kinase 1, or PINK1).

“GO and KEGG pathway analysis from RNA sequencing showed that PINK1/Parkin-mediated mitophagy pathway was enriched in 786-O-PR. Silencing SLC27A3 significantly reduced the accumulation of LD and ...