A cancer-causing protein long thought to be resistant to medication could soon be the target of new drugs, thanks to the work ...

Inside cells, two important enzymes act like small central regulatory hubs: dipeptidyl peptidase 8 and 9—DPP8/9 for short. Among other things, they regulate inflammatory reactions and influence ...

This important study shows, for the first time, the structure and snapshots of the dynamics of the full-length soluble Angiotensin-I converting enzyme dimer. The combination of structural and ...

Inhibiting key enzymes vital in replication could manage the dengue virus infection. This study investigated the potential of margolonone and isomargolonone from Azadirachta indica to inhibit dengue ...

However, the existing computational methods are insufficient and inefficient to exploit enzyme structure. In this work, we introduce SEFP, a novel method leveraging enzyme point clouds for enzyme ...

After this synthesis had been completed, preparation of Nα-benzoyl-dl-arginme-β-naphthylamide hydrochloride via the carbodiimide procedure was reported (cf. ref. 2). Gomori, G., J. Histochem ...

Our team showed that when we prompt an AI model, called RFdiffusion, with the structure and amino acid sequence of an active site, it can generate the rest of the enzyme structure that would ...

School of Chemistry, University of Leeds, Leeds LS2 9JT, U.K. Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, U.K. School of Chemistry, University of Leeds, Leeds ...

In this study, we unveil a common mechanism underlying these observations for the DNA-scaffolded enzymes that acts on enzymes independent of their catalytic mechanisms. By testing a variety of ...

Amino acids are the building blocks that form polypeptides and ultimately proteins. Consequently, they are fundamental components of our bodies and vital for physiological functions such as protein ...

A newfound signaling pathway employs a GGDEF enzyme with unique activity compared to the majority ... A 1.4 Å-resolution crystal structure of the Geobacter Hypr GGDEF domain was determined to ...