Systemic sclerosis (SSc) is a severe autoimmune disease with complex genetic causes. Some genetic contributors have been identified, but others remain unknown, which has impeded development of ...

The HLA complex on chromosome 6 contains over 200 genes, more than 40 of which encode leukocyte antigens (). 1–3 The rest are an assortment of genes that are not evolutionarily related to the ...

Scientists believe that the genes encoding the human leukocyte antigen (HLA), a protein expressed on the surface of leucocytes known to play an important role in the immune system, are involved in ...

Gene change may partly account for long Covid risk Genes may also help explain why people end up on the other side of the Covid-19 spectrum, dealing with symptoms that linger and turn into long Covid.

Variations in HLA genes have been associated with many illnesses, including human immunodeficiency virus, hepatitis B and hepatitis C. HLA genes hold the information needed to build molecules that ...

In one such experiment, in rats genetically manipulated to integrate two human genes, HLA-B27 and B2M, into their genomes, spontaneous inflammatory disease developed that resembled human ...

“What truly surprised and excited us was the discovery and replication of MICB, a gene located within the HLA region but acting independently of the classical HLA genes. MICB had not previously been ...