This paper addresses the important question of quantifying epistasis patterns, which affect the predictability of evolution, by reanalyzing a recently published combinatorial deep mutational scan ...

Trade, investment, and cross-border economic activity increased after India's economy was liberalized in the 1990s. The ...

NMDP allele codes identify groups of alleles that cannot be distinguished by genotyping methods that do not sequence the entire HLA gene. For example, the DRB1*11AD allele ... estimation involving ...

This manuscript describes an important finding of the transcriptional control of a chimeric gene transfer agents (GTA) cluster in Bartonella by a processive anti-termination factor (BrrG). The ...

An international panel of medical experts have thrust Lucy Letby back into the spotlight. At a press conference convened by ...

In this study, we developed a novel computational method to predict TOO of CUP patients by explicitly integrating expression quantitative trait loci (eQTL) into an XGBoost classification model. We ...

Chain-of-thought is a vital technique in prompting generative AI. Turns out that advanced AI does this implicitly. Problems ...

Let models explore different solutions and they will find optimal solutions to properly allocate inference budget to AI reasoning problems.

Methods This prospective cohort study included 400 229 participants from the UK Biobank. Cox regression and restricted cubic spline models and polygenic risk scores were employed to investigate the ...