Sufferers say the pain caused by the nerve disorder is so debilitating that they can’t smile, laugh or even make eye contact with another person.

The connection is both psychological and physiological: smiling activates the release of feel-good neurotransmitters like dopamine, serotonin, and endorphins, all of which play a role in reducing the ...

A new white paper exploring the correlation between smiling and pain reduction inspired a marathon activation that put a pep in the runners' step TARRYTOWN, N.Y., April 8, 2025 /PRNewswire ...

See images from the Smile 20 stunt at the Knoxville Marathon here . "We're all about helping people fight pain when they need it most, and no one needs it more than a marathoner," says Frank ...