Understanding the unique allosteric properties of CRPMTB may inform therapeutic strategies that target transcriptional ...

Despite the implied allosteric modulation of the M. tuberculosis 20S core particle ... use cryo-EM and HDX-MS to determine the 20S CP structure in an auto-inhibited state that is distinguished ...

Different types of immune cells form, so-called granulomas, in which M. tuberculosis can survive for years (latent infection). They fall into a permanently inactive state with reduced metabolic ...