Mandimycin, which targets a different essential fungi cell resource than other antifungal drugs, should harm other cell types as collateral — but doesn’t.

Antifungal drugs target molecules in the fungal cell wall, a flexible but rigid outer layer that provides the cell protection. By rupturing the protective structure, the drugs kill the fungal cell ...

This fascinating compound is a probable treasure trove of actionable intelligence in the battle against drug-resistant fungal infections ... as part of its chemical structure.

C. auris is often resistant to disinfectants and antifungal drugs, and can be difficult to kill. Between 30% and 60% of the people it infects will die. Around 3.8 million people die each year of ...