Cysteinyl leukotrienes (CysLTs) are potent bronchoconstrictors, playing pivotal roles in inflammatory diseases. These lipid ...

This important study shows, for the first time, the structure and snapshots of the dynamics of the full-length soluble Angiotensin-I converting enzyme dimer. The combination of structural and ...

Inhibiting key enzymes vital in replication could manage the dengue virus infection. This study investigated the potential of margolonone and isomargolonone from Azadirachta indica to inhibit dengue ...

"These images can be combined into a three-dimensional one, which gives us a precise insight into the structure of the complex ... with similar respiratory enzymes. More information: Anuj ...

Our team showed that when we prompt an AI model, called RFdiffusion, with the structure and amino acid sequence of an active site, it can generate the rest of the enzyme structure that would ...

School of Chemistry, University of Leeds, Leeds LS2 9JT, U.K. Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, U.K. School of Chemistry, University of Leeds, Leeds ...

In this study, we unveil a common mechanism underlying these observations for the DNA-scaffolded enzymes that acts on enzymes independent of their catalytic mechanisms. By testing a variety of ...

A newfound signaling pathway employs a GGDEF enzyme with unique activity compared to the majority ... A 1.4 Å-resolution crystal structure of the Geobacter Hypr GGDEF domain was determined to ...