In 1959, Bruce Merrifield, a Rockefeller chemist, devised a way to make peptide synthesis more efficient. Instead of working entirely in solution, Merrifield turned to a solid substrate. He attached ...

After a roller coaster ride of successes and failures, new discovery technologies and advances in manufacturing promise a brighter future for peptides in human therapy. Some 40 years after Nobel ...

Since Merrifield's seminal work on solid-phase peptide synthesis, chemists had been making efforts to assemble oligosaccharides in an analogous manner. The sequence analysis of complex ...