Am J Health Syst Pharm. 2011;68(15):1419-1425. The short duration of activity of naloxone when the drug is administered as an i.v. bolus may limit its effectiveness for the management of OIP.

Most organic drugs contain one acid group, usually a carboxylic acid, -COOH, or one basic primary, secondary, or tertiary amino group, NC 1-3, [3,22,27,28,29] that determines the acid-base ...

Cardiac arrest from opioid overdoses is usually secondary to respiratory arrest. Naloxone reverses narcotic overdoses by binding to opioid receptors, which blocks stimulation from the opioid ...