Most of the histamine release causes pruritus, which can be treated with around-the-clock antihistamine administration prior to administering opioid doses. Since most patients develop tolerance to ...

[205] Opioid tolerance is an increasingly prevalent challenge in perioperative care. Approximately 15 years ago, the concept of 'pain as the fifth vital sign' was popularized in the USA ...

For many pain relievers, particularly opioids, tolerance to the medications over time can limit their long-term effectiveness ...