In their quest to find compounds that alter disease-related proteins in new ways, researchers have developed so-called chemical inducers of proximity, or CIPs, which include molecular glues and ...

The current release of the database contains about 2.4 million activities of 622,824 compounds, measured against 7,192 targets, 4,364 of which are protein targets (the others are cell lines or ...

A new strategy for delivering bulky PROTACs to cancerous cells successfully utilizes the CD36 protein pathway on cells’ ...

Tuberculosis (TB) is an infectious disease that kills more than a million people worldwide every year. The pathogen that ...

An immunoblotting technique determined that the probe interacts with a specific receptor — a protein known as TREM2 — on ...

Another reason for choosing a particular modality is that it is a team’s specialty. Strategic choices can be less about determining which modality best fits a potential target than about choosing a ...

Their pioneering work has been featured as a Supplementary Cover in the Journal of the American Chemical Society ... reactive sites on a target protein. The dOxa compound proved approximately ...

However, the chemical components of traditional ... stability of the complexes formed between the active compounds and the corresponding proteins. This study highlights the potential application ...