A major new initiative, launched on 15 April, will map how gene activity shapes the immune system, and could help identify new therapeutic targets for conditions such as Inflammatory Bowel Disease ...

Complete Genomics, a leading innovator in genomic sequencing, today announced four winners from 30 applicants to its Spatial Xcellerator Grant Program. Winning projects address oncology, pediatric ...

Research on gastrointestinal diseases, especially cancer, has mainly focused on epithelial cells, which line the surfaces of ...

Top-down proteomics: Intact proteins are ionized and analyzed directly, allowing for the study of proteoforms and ...

Spatial biology first entered the omics scene about a decade ago. Since then, the technology has generated significant buzz ...

The Postdoctoral Scholar will lead innovative research projects focused on the development and evaluation of immunotherapies for brain tumors, with an emphasis on CAR-T cell therapy. This position ...

On the methodological side, the researchers combined several advanced techniques—single-cell analysis, single-nucleus sequencing, and spatial transcriptomics—to get a detailed view of gene activity ...

Molecularly defined serotonin (enterochromaffin) cells of the gut lining were distinguished by single-cell expression analysis, in situ hybridization, and immunohistochemistry into 14 topographically ...

By creating comprehensive maps of the locations of gene expression in tissue, spatial transcriptomics technologies have made ...

Spatial transcriptomics technologies opened the door for new kinds of biological measurements, allowing scientists to ...

The study is useful for advancing spatial transcriptomics through its novel regression-based linear model (glmSMA) that integrates single-cell RNA-seq with spatial reference atlases, though its ...

Abstract: Current spatial transcriptomics (ST) technology can integrate stained pathological slides with RNA sequencing, providing precise information on gene expression and cell types. However, the ...