The San Francisco 49ers made a trenches pick on Day 1 of the 2025 NFL Draft, selecting Georgia Bulldogs defensive end Mykel Williams at No. 11 overall, taking one of the youngest players in the draft to fill a need.

Those 20 departures include 13 unrestricted free agents, two players traded and five that were released. They played a total of 209 games in 2024 with 115 starts. Several of those had low games numbers because of injuries. Some replacements came in the UFA market, as the 49ers added nine players that played 140 games with 56 starts last season.