Experts have known for several decades that the PINK1 protein is directly linked to Parkinson’s disease – the fastest growing ...

First discovered more than 20 years ago, PINK1 is a protein directly linked to Parkinson’s disease, but until now, no one has seen what human PINK1 looks like, or how PINK1 attaches to ...

But in a recent paper published in Science, researchers have had their first good gawk at the protein linked to the development of the condition (PTEN-induced putative kinase 1, or PINK1).

View Full Profile. Learn about our Editorial Policies. PINK1 triggers a downstream cascade of events that leads to mitophagy—a process by which the cell clears away any mitochondria it doesn’t need. 4 ...

A report published in PLoS Biology provides evidence that PTEN-induced putative kinase 1 (PINK1) is involved in selective autophagy of dysfunctional mitochondria. Recessive mutations in the PINK1 ...

Two of the proteins, Parkin and PINK1, hang around the mitochondria’s membrane and work as a pair to enable the mitochondria to fuse or degrade. Abnormalities in the genes for Parkin and PINK1 are ...

“GO and KEGG pathway analysis from RNA sequencing showed that PINK1/Parkin-mediated mitophagy pathway was enriched in 786-O-PR. Silencing SLC27A3 significantly reduced the accumulation of LD and ...

Our most recent work is focused on elucidating how a protein kinase (PINK1) controls the activity of a ubiquitin E3 ligase (Parkin) to specify cell fate decisions. Mutations in genes encoding for ...